Is Pancreatic Cancer Hereditary? Understanding Genetic Risk Factors with Dr. Syed Hassanujjaman
Pancreatic cancer is a highly aggressive disease, often detected in the later stages. One of the key concerns for individuals with a family history of pancreatic cancer is whether the disease is hereditary. Dr. Syed Hassanujjaman, a leading cancer specialist in Kolkata, explains the genetic risk factors associated with pancreatic cancer and the importance of early detection.
Can Pancreatic Cancer Be Inherited?
While most cases of pancreatic cancer occur due to lifestyle and environmental factors, around 10-15% of cases are linked to inherited genetic mutations. If one or more close family members have had pancreatic cancer, the risk increases significantly.
Genetic Mutations Linked to Pancreatic Cancer
Certain genetic mutations increase the risk of pancreatic cancer, including:
BRCA1 & BRCA2 – Known for breast and ovarian cancer risk, these mutations also increase pancreatic cancer susceptibility.
PALB2 – A gene that affects DNA repair, raising pancreatic cancer risk.
CDKN2A – Associated with melanoma and pancreatic cancer.
TP53 – A mutation linked to Li-Fraumeni Syndrome, which increases the risk of multiple cancers.
STK11 (Peutz-Jeghers Syndrome) – Raises the risk of pancreatic, stomach, and intestinal cancers.
ATM Gene – Plays a role in DNA damage repair, increasing cancer risk.
If you have a family history of pancreatic cancer, genetic testing can help assess your personal risk and guide early prevention strategies.
Who Is at Higher Risk?
Your pancreatic cancer risk increases if:
Two or more first-degree relatives (parents, siblings) had pancreatic cancer.
A close family member was diagnosed at a young age.
There is a history of other hereditary cancers (breast, ovarian, colorectal).
Should You Consider Genetic Testing?
Dr. Syed Hassanujjaman recommends genetic testing for individuals who:
Have multiple family members with pancreatic or other hereditary cancers.
Have a known BRCA, Lynch Syndrome, or Peutz-Jeghers Syndrome mutation in the family.
Were diagnosed with pancreatic cancer at a young age (below 50).
A genetic counselor can help determine if screening and preventive measures are necessary.
How to Lower the Risk of Pancreatic Cancer
Although genetic factors cannot be changed, lifestyle choices can help reduce the risk:
Quit Smoking – Smoking is a leading risk factor for pancreatic cancer.
Maintain a Healthy Weight – Obesity significantly increases the risk.
Eat a Balanced Diet – A diet rich in fruits, vegetables, and whole grains lowers the risk.
Limit Alcohol Consumption – Excessive alcohol can cause pancreatic damage.
Regular Screenings – Those with a family history should undergo early detection tests like MRI or endoscopic ultrasound.
Expert Opinion: Dr. Syed Hassanujjaman on Pancreatic Cancer Prevention
“Understanding your genetic risk can be life-saving. If you have a strong family history of pancreatic cancer, early screening and lifestyle modifications can make a significant difference. Genetic testing is an important step toward personalized cancer prevention.” – Dr. Syed Hassanujjaman
Final Thoughts
If you are concerned about your pancreatic cancer risk, consult Dr. Syed Hassanujjaman for genetic counseling, early screening, and expert advice on cancer prevention.
Book an Appointment Today!